1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid synthesis

14synthesis methods

Product Name:1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid
CAS Number:85858-95-3
Molecular formula:C12H14O3
Molecular Weight:206.24

1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-7-methoxy-, methyl ester

218597-25-2
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1,2,3,4-Tetrahydro-7-methoxy-1-naphthalenecarboxylic acid

85858-95-3
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Yield:85858-95-3 100%

Reaction Conditions:

with lithium hydroxide

Steps:

d

d) (R,S)-7-Methoxy-1,2,3,4-tetrahydro-naphthalene-1-carboxylic acid (5d) Compound 5c (2.2 g, 10 mmol) was hydrolyzed by lithium hydroxide (2.10 g, 50 mmol) to the title acid (2.03 g,~100%). ¹H NMR (300 MHz, DMSO-d₆) δ: 12.38 (s, 1H), 6.99 (d, 1H), 6.74 (dd, 1H), 6.69 (d, 1H), 3.68 (s, 3H), 3.66 (m, 1H), 2.64 (m, 2H), 2.05-1.68 (m, 4H).

References:

US2005/54630,2005,A1 Location in patent:Page/Page column 34