N-methyl-1-[3-(2-thienyl)-1H-pyrazol-5-yl]methanamine(SALTDATA: FREE) synthesis

2synthesis methods

Product Name:N-methyl-1-[3-(2-thienyl)-1H-pyrazol-5-yl]methanamine(SALTDATA: FREE)
CAS Number:859850-81-0
Molecular formula:C9H11N3S
Molecular Weight:193.27

N-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxamide

1239511-44-4
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N-methyl-1-[3-(2-thienyl)-1H-pyrazol-5-yl]methanamine(SALTDATA: FREE)

859850-81-0
8 suppliers
$171.00/500mg

Yield:859850-81-0 88%

Reaction Conditions:

Stage #1: 5-(2-thienyl)-1H-pyrazole-3-(N-methyl)carboxamidewith lithium aluminium tetrahydride in tetrahydrofuran at 35; for 8 h;Reflux;
Stage #2: with potassium hydroxide in tetrahydrofuran;water; for 2 h;Reflux;
Stage #3: with hydrogenchloride in 1,4-dioxane;water; for 6 h;Reflux;

References:

Musatov;Starodubtseva;Rakishev;Turova;Vinogradov [Russian Journal of Organic Chemistry,2011,vol. 47,# 8,p. 1199 - 1203] Location in patent:experimental part

88-15-3
599 suppliers
$5.00/10g

859850-81-0
8 suppliers
$171.00/500mg

References