1-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid synthesis

1synthesis methods

Product Name:1-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid
CAS Number:861151-23-7
Molecular formula:C16H13ClN2O2
Molecular Weight:300.74

Ethyl 1-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate

861151-22-6
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1-(4-Chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid

861151-23-7
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Yield:861151-23-7 85%

Reaction Conditions:

with potassium hydroxide in methanol at 65 - 68; for 2 h;

References:

Srivastava, Brijesh Kumar;Joharapurkar, Amit;Raval, Saurin;Patel, Jayendra Z.;Soni, Rina;Raval, Preeti;Gite, Archana;Goswami, Amitgiri;Sadhwani, Nisha;Gandhi, Neha;Patel, Harilal;Mishra, Bhupendra;Solanki, Manish;Pandey, Bipin;Jain, Mukul R.;Patel, Pankaj R. [Journal of Medicinal Chemistry,2007,vol. 50,# 24,p. 5951 - 5966]