![](/CAS/20180601/GIF/862112-25-2.gif)
5-(Trifluoromethyl)-1H-1,2,3-Triazole-4-Carboxylic Acid synthesis
- Product Name:5-(Trifluoromethyl)-1H-1,2,3-Triazole-4-Carboxylic Acid
- CAS Number:862112-25-2
- Molecular formula:C4H2F3N3O2
- Molecular Weight:181.07
![2H-1,2,3-Triazole-4-carboxylic acid, 5-(trifluoromethyl)-, ethyl ester](/CAS/20210305/GIF/942060-33-5.gif)
942060-33-5
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![5-(Trifluoromethyl)-1H-1,2,3-Triazole-4-Carboxylic Acid](/CAS/20180601/GIF/862112-25-2.gif)
862112-25-2
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Yield:-
Reaction Conditions:
Stage #1: ethyl 5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxylatewith sodium hydroxide in water; for 1.5 h;Heating / reflux;
Stage #2: with hydrogenchloride in water;
Steps:
38.1
Ethyl 5-(trifluoromemyl)-lNo."-l52,3-triazole-4-carboxylate (0.312 g) was stirred inaqueous N sodium hydroxide (3.8 mL) and heated under reflux for 90 min. The cooled5 solution was acidified with aqueous hydrochloric acid and extracted with ethyl acetate. Theextracts were washed with brine then dried and evaporated to leave a colourless solid(0.226 g).MS (ES-ve) 180 [M-H]"
References:
WO2005/73192,2005,A1 Location in patent:Page/Page column 56