Carbamic acid, [(1S)-1-(cyclopropylcarbonyl)-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI) synthesis
- Product Name:Carbamic acid, [(1S)-1-(cyclopropylcarbonyl)-2-methylpropyl]-, 1,1-dimethylethyl ester (9CI)
- CAS Number:864185-86-4
- Molecular formula:C13H23NO3
- Molecular Weight:241.33
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Yield:864185-86-4 43.1%
Reaction Conditions:
in tetrahydrofuran at 0 - 20; for 5.25 h;
Steps:
4.A
To amide 4a (0.5 g, 1 eq) in THF was added cyclopropylmagnesium bromide (4 eq, 7.68 mmol) at 0° C. The reaction was warmed up to RT after 1 5min and the reaction was stirred at RT for 5 hrs, then it was quenched by the addition of 1 N HCl. Reaction was diluted with EtOAc and washed with brine. The organic layer was dried over MgSO4, purified by column chromatography with 10% EtOAc in hexane to get 0.2 g of product 4b. Yield 43.1%.
References:
US2005/197301,2005,A1 Location in patent:Page/Page column 124