(3aR*,6aS*)-tetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione(SALTDATA: HCl 0.5H2O) synthesis

Yield: 75%

Reaction Conditions:

with hydrogen;palladium(II) hydroxide in methanol at 45;

Steps:

2
Step 2Pd(OH)₂ (0.3gm,30% by weight) was added to a solution of compound [146] in MeOH. The resulting mixture was kept under the pressure of a balloon filled with H₂. The reaction mixture was heated at 45 °C overnight. The reaction was monitored by TLC. After completion of reaction Pd(OH)₂ was filtered out by using celite pad. The filtrate was concentrated on buchi rotavapour under reduced pressure to afforded [147] as a white solid in 75 % yield.

References:

SPHAERA PHARMA PVT. LTD;DUGAR, Sundeep;MAHAJAN, Dinesh;DEOKAR, Rhushikesh, Chandraban;HOLLINGER, Frank, Peter;KAPOOR, Kamal, Kishore WO2012/101654, 2012, A2 Location in patent:Page/Page column 74-75