Benzenepentanoic acid, 4-fluoro-δ-hydroxy-, methyl ester, (δS)- synthesis

Yield:870634-36-9 100%

Reaction Conditions:

Stage #1: 5-(4-fluorophenyl)-5-oxopentanoic acid methyl esterwith sodium t-butanolate;poly(methylhydrosiloxane);(S)-(-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl;copper(l) chloride in toluene at -50 - 0; for 24.4 h;Cooling with isopropanol/dry ice;
Stage #2: with water;acetic acid in toluene at -10 - 0; for 1.5 - 2 h;Product distribution / selectivity;

References:

WO2005/113495,2005,A1 Location in patent:Page/Page column 56-58