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ethyl 5-methyl-2-(4-(trifluoromethyl)phenyl)-2H-1,2,3-triazole-4-carboxylate(WXG00619)
ethyl 5-methyl-2-(4-(trifluoromethyl)phenyl)-2H-1,2,3-triazole-4-carboxylate(WXG00619) synthesis
2synthesis methods
- Product Name:ethyl 5-methyl-2-(4-(trifluoromethyl)phenyl)-2H-1,2,3-triazole-4-carboxylate(WXG00619)
- CAS Number:870788-48-0
- Molecular formula:C13H12F3N3O2
- Molecular Weight:299.25
Yield:870788-48-0 63.7%
Reaction Conditions:
Stage #1: 4-trifluoromethylphenylaminewith hydrogenchloride;sodium nitrite in water;acetic acid at 0;
Stage #2: ethyl acetoacetatewith sodium acetate;sodium carbonate in ethanol;water;acetic acid at 0 - 20; for 2 h;
Stage #3: with copper(II) choride dihydrate;ammonium acetate in ethanol; for 20 h;Reflux;
References:
Kress, Brian J.;Kim, Dong Hyun;Mayo, Jared R.;Farris, Jeffery T.;Heck, Benjamin;Sarver, Jeffrey G.;Andy, Divya;Trendel, Jill A.;Heck, Bruce E.;Erhardt, Paul W. [Journal of Medicinal Chemistry,2021,vol. 64,# 10,p. 6996 - 7032]
