ChemicalBook CAS DataBase List N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester

N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester synthesis

7synthesis methods

Product Name:N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester
CAS Number:870812-30-9
Molecular formula:C20H24N2O3S
Molecular Weight:372.48

870812-29-6 Synthesis

N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester

870812-29-6
14 suppliers
$120.09/10mg

882-33-7 Synthesis

882-33-7
296 suppliers
$10.00/5g

N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester

870812-30-9
15 suppliers
$95.00/5mg

Yield:870812-30-9 95%

Reaction Conditions:

with tributylphosphine in toluene at 80; for 16 h;

Steps:

1.1K benzyl (1R)-3-(dimethylamino)-3-oxo-1-((phenylsulfanyl)methyl)propylcarbamate

EXAMPLE 1K benzyl (1R)-3-(dimethylamino)-3-oxo-1-((phenylsulfanyl)methyl)propylcarbamate A solution of EXAMPLE 1J (8.45 g, 30.14 mmol) in toluene (15 mL) was treated with tributylphosphine (9.76 mL, 39.20 mmol), diphenyldisulfide (7.30 g, 39.20 mmol) and heated to 80° C. for 16 hours. The reaction mixture was concentrated and purified by column chromatography on silica gel eluding with a gradient of 0-50% ethyl acetate in hexanes to give the desired product (10.62 g, 95%). MS (CI) m/e 373 (M+H)⁺.

References:

US2005/272744,2005,A1 Location in patent:Page/Page column 11-12