4-CHLORO-3-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID synthesis
- Product Name:4-CHLORO-3-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID
- CAS Number:871332-75-1
- Molecular formula:C11H13BClNO3
- Molecular Weight:253.49
123-75-1
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$10.00/5g
21739-92-4
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$8.00/10g
871332-75-1
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$42.00/100mg
Yield:871332-75-1 51%
Reaction Conditions:
Stage #1: pyrrolidine;5-bromo-2-chlorobenzoic acidwith benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;N-ethyl-N,N-diisopropylamine in acetonitrile;
Stage #2: with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate;bis(pinacol)diborane in 2-methyltetrahydrofuran;
Stage #3: with hydrogenchloride;sodium periodate in 2-methyltetrahydrofuran;water;
References:
Zhu, Jason;Razler, Thomas M.;Xu, Zhongmin;Conlon, David A.;Sortore, Eric W.;Fritz, Alan W.;Demerzhan, Roman;Sweeney, Jason T. [Organic Process Research and Development,2011,vol. 15,# 2,p. 438 - 442] Location in patent:scheme or table