4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-(chloromethyl)-1,5-dihydro-1-phenyl- synthesis
- Product Name:4H-Pyrazolo[3,4-d]pyrimidin-4-one, 6-(chloromethyl)-1,5-dihydro-1-phenyl-
- CAS Number:871478-89-6
- Molecular formula:C12H9ClN4O
- Molecular Weight:260.68
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Yield:871478-89-6 58%
Reaction Conditions:
at 20 - 200; for 5.5 h;
Steps:
1-Substitutedphenyl-6-(chloromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one(3a,b)
A well stirred mixture of 5-amino-1-phenyl -1H-pyrazole -4-carboxamide (1mmol,1a) and choloroacetyl chloride (0.113g (0.079mL),1mmol) for about 30min at room temperature, which was then heated at 200°C in oil bath for 5h, the solid formed was triturated with ethanol, then filtered, dried and crystalized from acetic acid.
References:
AbdEl-Ghany, Ahmed A.;Elshaier, Yaseen A. M. M.;Farag, Nahla A.;Hammad, Ali H.;Hassan Haredy, Haredy;Mohamed, Khaled O.;Shaaban, Mohamed A. [Bioorganic and medicinal chemistry letters,2020,vol. 30,# 16]
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5334-43-0
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