2-Pyridinecarboxylic acid, 5-amino-3-methoxy-, ethyl ester synthesis
- Product Name:2-Pyridinecarboxylic acid, 5-amino-3-methoxy-, ethyl ester
- CAS Number:872355-72-1
- Molecular formula:C9H12N2O3
- Molecular Weight:196.2
75711-01-2
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Yield:-
Reaction Conditions:
with triethylamine;palladium diacetate;1,3-bis-(diphenylphosphino)propane at 60; for 18.1667 h;
Steps:
13.D
The 2-chloro-3-methoxy-5-aminopyridine (1.83 g, 11.58 mmol) was dissolved in EtOH (50 mL) and palladium acetate (2.0 g, 9.0 mmol), l,3-bis(diphenylphosphino)propane (3.5 g, 5.3 mmol), triethylamine (8.4 g, 83.38 mmol) were added sequentially and a stream of carbon monoxide was bubbled through the solution for 10 min. A balloon filled with CO was attached to the reaction flask and the mixture was stirred at 60 0C for 18 h. The mixture was cooled and diluted with ethyl acetate, filtered through a pad of Celite and evaporated. Purification using silica gel chromatography using hexane/ethyl acetate mixture provided 310 mg of product.
References:
WO2006/112828,2006,A1 Location in patent:Page/Page column 91
16867-04-2
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