4-[(ISOPROPYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 98%4-(3-ISOPROPYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER synthesis
- Product Name:4-[(ISOPROPYLCARBAMOYL)AMINO]BENZENEBORONIC ACID, PINACOL ESTER 98%4-(3-ISOPROPYLUREIDO)BENZENEBORONIC ACID, PINACOL ESTER
- CAS Number:874291-02-8
- Molecular formula:C16H25BN2O3
- Molecular Weight:304.19
214360-73-3
327 suppliers
$8.00/1g
1795-48-8
175 suppliers
$24.73/250mgs:
874291-02-8
33 suppliers
$45.00/100mg
Yield:-
Reaction Conditions:
in dichloromethane at 20;
Steps:
2. 1. the procedure for the preparation of intermediate product (1)
General procedure: To a solution of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) aniline (1.1 g, 0.5 mmol, 1.0 eq.) and isocyanate (2-isocyanatopropane,isocyanatocyclopropane,isocyanatocyclopentane,isocyanatocyclohexane,1-isocyanato-4-methylbenzene,1-isocyanato-4-methoxybenzene,1-isocyanato-4-(trifluoromethoxy)benzene,1-chloro-4-isocyanatobenzene,1-fluoro-4-isocyanatobenzene,1-isocyanato-4-(trifluoromethyl)benzene) (0.5 mmol, 1.0 eq.) in DCM (10 mL) were stirred at room temperature for 8~72 h. Upon completion of the reaction, The residue was filtered and concentrated under vacuum to afforded solid. yield: 90%~97%.
References:
Wu, Xiuli;Liu, Zhihao;Gan, Cailin;Wei, Wei;Zhang, Qianyu;Liu, Hongyao;Que, Hanyun;Su, Xingping;Yue, Lin;He, Hualong;Ouyang, Liang;Ye, Tinghong [Bioorganic Chemistry,2022,vol. 127,art. no. 105965] Location in patent:supporting information