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3-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide synthesis

2synthesis methods
41838-46-4 Synthesis
1-Methylpiperidin-4-amine

41838-46-4
260 suppliers
$6.00/1g

5081-36-7 Synthesis
3-Methoxy-4-nitrobenzoic acid

5081-36-7
212 suppliers
$6.00/1g

3-methoxy-N-(1-methylpiperidin-4-yl)-4-nitrobenzamide

876126-59-9
5 suppliers
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Yield:876126-59-9 90%

Reaction Conditions:

with O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate;triethylamine in N,N-dimethyl-formamide at 20; for 16 h;Inert atmosphere;

References:

Chen, Lijia;Yap, Jeremy L.;Yoshioka, Makoto;Lanning, Maryanna E.;Fountain, Rachel N.;Raje, Mithun;Scheenstra, Jacob A.;Strovel, Jeffrey W.;Fletcher, Steven [ACS Medicinal Chemistry Letters,2015,vol. 6,# 7,p. 764 - 769] Location in patent:supporting information