Carbamic acid, (4,5-dihydro-4-oxo-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI) synthesis
- Product Name:Carbamic acid, (4,5-dihydro-4-oxo-2-thiazolyl)-, 1,1-dimethylethyl ester (9CI)
- CAS Number:879324-03-5
- Molecular formula:C8H12N2O3S
- Molecular Weight:216.26
24424-99-5
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879324-03-5
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Yield: 86%
Reaction Conditions:
in tetrahydrofuran at 60; for 48 h;
Steps:
H.1
Pseudothiohydantoin (5.82 g, 50 mmol) and di-t-butyl dicarbonate (21.82 g, 100 mmol) were combined in dry THF (100 mL) and stirred at 60° C. for 48 h. The cooled mixture was treated with decolorizing carbon and filtered through diatomaceous earth rinsing with THF. The filtrate was concentrated to a damp solid which was triturated with hexane. The resulting solid was collected and rinsed with hexane yielding 9.35 g (86%) of the title compound as a light tan solid.
References:
Reiter, Lawrence A.;Linde, Robert G. US2008/76771, 2008, A1 Location in patent:Page/Page column 17
24424-99-5
832 suppliers
$13.50/25G
556-90-1
169 suppliers
$6.00/1g
879324-03-5
13 suppliers
$90.00/100mg