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3-(Chloromethyl)-1,3-diazaspiro[4.5]decane-2,4-dione synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 80 percent / H2O / 16 h / 70 °C
2: 96 percent / thionyl chloride / 16 h / Ambient temperature

References:

Haces;Driscoll;Roth;Heideman;Kelley [Journal of Pharmaceutical Sciences,1986,vol. 75,# 3,p. 313 - 316]