3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide synthesis
- Product Name:3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide
- CAS Number:880652-44-8
- Molecular formula:C10H9BrF3NO2
- Molecular Weight:312.08
Yield:880652-44-8 83%
Reaction Conditions:
with triethylamine;HATU in dichloromethane at 20;
Steps:
30.1
Step 1 : 3-Bromo-A -methoxy-/V-methyl-5-(trifluoromethyl)benzamide (P30a)To a solution of 3-bromo-5-(trifluoromethyl)benzoic acid (5.34 g, 20 mmol) in DCM (120 mL) was added 0,/V-dimethylhydroxylamine hydrochloride (2.9 g, 30 mmol), HATU (9.2 g, 30 mmol) and Et3N (8.0 g, 80 mmol). The mixture was stirred at rt overnight, concentrated and purified by CC (hexane) to afford compound P30a (5.1 g, 83%) as a solid.
References:
WO2012/139775,2012,A1 Location in patent:Page/Page column 56
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