1H-Pyrrole-3-carboxylic acid, 5-bromo-4-ethyl-, methyl ester synthesis

Yield:-

Reaction Conditions:

with N-Bromosuccinimide

Steps:

R.98 Methyl 5-bromo-4-ethyl-1H-pyrrole-3-carboxylate

Reference Example 98 Methyl 5-bromo-4-ethyl-1H-pyrrole-3-carboxylate Using methyl 4-ethyl-1H-pyrrole-3-carboxylate (2.32 g) and N-bromosuccinimide (2.74 g), a procedure as in Reference Example 40 was performed to give the title compound as white crystals (yield 2.96 g, 84%). ¹H-NMR (CDCl₃)δ: 1.13 (3H, t, J=4.5 Hz), 2.70 (2H, q, J=4.5 Hz), 3.81 (3H, s), 7.37 (1H, d, J=3.0 Hz), 8.30 (1H, brs).

References:

EP1803709,2007,A1