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ChemicalBook CAS DataBase List 2-Acetamido-3-(6-(benzyloxy)-1H-indol-3-yl)propanoic acid

2-Acetamido-3-(6-(benzyloxy)-1H-indol-3-yl)propanoic acid synthesis

7synthesis methods
-

Yield:88208-17-7 82%

Reaction Conditions:

Stage #1: L-serin;acetic anhydridewith acetic acid at 20; for 16 h;Inert atmosphere;
Stage #2: 6-benzyloxy-1H-indole at 75; for 2 h;Inert atmosphere;

References:

Knittel, Caroline H.;Süssmuth, Roderich D.;Siegert, Mary-Ann J. [Angewandte Chemie - International Edition,2020,vol. 59,# 14,p. 5500 - 5504][Angew. Chem.,2020,vol. 132,p. 5542 - 5546,5] Location in patent:supporting information