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4-(chloromethyl)-2-(3-fluorophenyl)-5-methyl-1,3-oxazole(SALTDATA: FREE) synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: hydrogenchloride / ethyl acetate / 0 - 20 °C
2: trichlorophosphate / acetonitrile / 0 - 20 °C

References:

Shibata, Yoshihiro;Kagechika, Katsuji;Yamaguchi, Mitsuhiro;Yoshikawa, Kenji;Chiba, Kiyoshi;Takano, Hiromichi;Akiyama, Chiyuki;Ono, Mayumi;Nishi, Mina;Kubo, Hideo;Kobayashi, Yoshimasa;Usui, Hiroyuki [Chemical and Pharmaceutical Bulletin,2013,vol. 61,# 12,p. 1248 - 1263]