ChemicalBook CAS DataBase List 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide

5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide synthesis

3synthesis methods

Product Name:5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide
CAS Number:885223-63-2
Molecular formula:C8H8BrClN2O2
Molecular Weight:279.52

29241-65-4 Synthesis

29241-65-4
244 suppliers
$6.00/1g

1117-97-1
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5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide

885223-63-2
31 suppliers
$55.00/250mg

Yield:885223-63-2 90%

Reaction Conditions:

Stage #1: 5-bromo-2-chloronicotinic acidwith 1,1'-carbonyldiimidazole in dichloromethane at 20; for 1 h;
Stage #2: N,0-dimethylhydroxylamine in dichloromethane at 20;

Steps:

D-2

Example D-2: Preparation of (2S)-1 -(4-(1 -isopropyl-3-(3-methyl-1 H-pyrazolo[3,4-b]pyridin-5-yl)-1 H- pyrazol-4-yi)pyrimidin-2-ylamino)propan-2-ol D-2-1 D-2-2 D-2-3Preparation of S-bromo^-chloro-N-methoxy-N-methylnicotinamide (D-2-2).D-2-1 D-2-2To a solution of compound D-2-1 (23.5 g, 0.1 mol) in dry CH₂CI₂ (400 mL) was added CDI (19.5 g, 0.12 mol) portionwise at room temperature under N₂ atmosphere. After the addition, the mixture was stirred for 1 hour. O,N-dimethyl-hydroxylamine (11.5 g, 0.12 mol) was then added portionwise at room temperature. After the addition, the resulting mixture was stirred at room temperature overnight. TLC (petroleum ether/EtOAc 8:1 ) indicated complete consumption of starting material. H₂O (200 mL) was added and the organic layer was separated, washed with 1 N HCI (100 mL), 1 N Na₂CO₃ (100 mL) and saturated aqueous NaCI (200 ml_) in sequence, dried over Na₂SO₄ and concentrated in vacuo to give compound D- 2-2 (25 g, 90%) as a yellow solid.

References:

WO2009/16460,2009,A2 Location in patent:Page/Page column 102-104

6638-79-5 Synthesis

6638-79-5
559 suppliers
$6.00/25g

29241-65-4 Synthesis

29241-65-4
244 suppliers
$6.00/1g

885223-63-2
31 suppliers
$55.00/250mg

References

6638-79-5 Synthesis

6638-79-5
559 suppliers
$6.00/25g

78686-86-9 Synthesis

5-BROMO-2-CHLORO-3-PYRIDINECARBONYL CHLORIDE

78686-86-9
23 suppliers
$106.04/250mgs:

885223-63-2
31 suppliers
$55.00/250mg

References

5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide Related Search:

N-Methoxy-N-Methyl 5-broMo-2-chlorobenzaMide