4-[CARBOXY-(4-CHLORO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE synthesis

4synthesis methods

Product Name:4-[CARBOXY-(4-CHLORO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
CAS Number:885273-01-8
Molecular formula:C17H23ClN2O4
Molecular Weight:354.83

1-Piperazineacetic acid, α-(4-chlorophenyl)-4-[(1,1-dimethylethoxy)carbonyl]-, methyl ester

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4-[CARBOXY-(4-CHLORO-PHENYL)-METHYL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE

885273-01-8
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Yield:885273-01-8 43.4%

Reaction Conditions:

with water;sodium hydroxide in ethanol; for 4 h;

Steps:

4.2.8 General synthesis of compounds 13

General procedure: To a solution of 12 (1mmol) in 3mL of ethanol/water (2/1), 2mL of 1N aqueous sodium hydroxide solution (2mmol) were added and the mixture was stirred at room temperature for 4h. The organic solvents were removed under reduced pressure and the resulting aqueous solution was adjusted in an ice bath to pH 6 using 1N aqueous hydrochloric acid. The resulting solid was filtered, washed with water to obtain 13.

References:

Chen, Xin;Guo, Kaiwen;Liu, Yang;Ran, Fansheng;Zhang, Zhen;Zhao, Guisen [Bioorganic Chemistry,2020,vol. 97]

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References

methyl 2-bromo-2-(4-chlorophenyl)acetate

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885273-01-8
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References

1878-66-6
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