ChemicalBook CAS DataBase List 2-(3-AMINO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

2-(3-AMINO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER synthesis

4synthesis methods

Product Name:2-(3-AMINO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
CAS Number:885274-73-7
Molecular formula:C12H12N2O3
Molecular Weight:232.24

4-Oxazolecarboxylic acid, 2-(3-nitrophenyl)-, ethyl ester

1279818-81-3
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2-(3-AMINO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

885274-73-7
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Yield:885274-73-7 87%

Reaction Conditions:

with palladium on activated charcoal;hydrogen in 1,4-dioxane; under 760.051 Torr;

Steps:

19.C STEP C. Intermediate 19C. Preparation of ethyl 2-(3-aminophenyl)oxazole-4-carboxylate

A stirred solution of Intermediate 19B (1 g, 3.81 mmol) in 1,4-dioxane (20 mL) was purged and flushed with nitrogen. Pd-C (0.20 g, 1.91 mmol) was added to the reaction mixture and stirred under hydrogen (1 atm, balloon) overnight. The reaction mixture was filtered through Celite and the filtrate was concentrated under reduced pressure to afford title compound (800 mg, 3.31 mmol, 87% yield). MS (ESI) 233 (M+H).

References:

WO2020/168148,2020,A1 Location in patent:Page/Page column 113-115

Carbamic acid, N-[3-(aminocarbonyl)phenyl]-, phenylmethyl ester

950603-66-4
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885274-73-7
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References

3544-24-9 Synthesis

3544-24-9
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$5.00/100mg

885274-73-7
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References

99-61-6 Synthesis

99-61-6
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$5.00/10g

885274-73-7
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References