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5-FLUORO-2,3-DIHYDRO-BENZOFURAN-3-YLAMINE HYDROCHLORIDE synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 0 - 20 °C
2: water / tetrahydrofuran / 2 h / 50 °C

References:

Pettersson, Martin;Johnson, Douglas S.;Subramanyam, Chakrapani;Bales, Kelly R.;Am Ende, Christopher W.;Fish, Benjamin A.;Green, Michael E.;Kauffman, Gregory W.;Lira, Ricardo;Mullins, Patrick B.;Navaratnam, Thayalan;Sakya, Subas M.;Stiff, Cory M.;Tran, Tuan P.;Vetelino, Beth C.;Xie, Longfei;Zhang, Liming;Pustilnik, Leslie R.;Wood, Kathleen M.;O'Donnell, Christopher J. [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 8,p. 2906 - 2911]