4-ALLYL-5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL synthesis
- Product Name:4-ALLYL-5-(4-METHOXYPHENYL)-4H-1,2,4-TRIAZOLE-3-THIOL
- CAS Number:88614-18-0
- Molecular formula:C12H13N3OS
- Molecular Weight:247.32
![Benzoic acid, 4-Methoxy-, 2-[(2-propen-1-ylaMino)thioxoMethyl]hydrazide](/CAS/20150408/GIF/117026-15-0.gif)
117026-15-0
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88614-18-0
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Yield:88614-18-0 69.5%
Reaction Conditions:
with sodium hydroxide for 3 h;Reflux;
Steps:
3 4.1.3. General procedure for the synthesis of 4-allyl/phenyl-5-aryl-4H-1,2,4-triazole-3-thiol derivatives (4a-j) [59,60]
General procedure: Equimolar quantities of the benzohydrazides 3a-e (0.1mol) and allyl/phenyl isothiocyanate (0.1mol) in 125mL of absolute ethanol were heated under reflux for 4h. The solvent was evaporated under vacuum. The resulting solid was filtered off, dried and used for the following step as a crude product. A mixture of the crude products (10mmol) and 100mL of 2N NaOH was heated under reflux for 3h. The reaction mixture was cooled and acidified to pH 2 with concentrated HCl. The solid that precipitated was filtered off, washed with water, and recrystallized from 95% ethanol [59].
References:
Ahmed, Fatma F.;Abd El-Hafeez, Amer Ali;Abbas, Samar H.;Abdelhamid, Dalia;Abdel-Aziz, Mohamed [European Journal of Medicinal Chemistry,2018,vol. 151,p. 705 - 722]
3290-99-1
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88614-18-0
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$28.60/10MG
100-09-4
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88614-18-0
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94-30-4
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88614-18-0
19 suppliers
$28.60/10MG