METHYL 2-AMINO-5-(4-FLUOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE synthesis
1synthesis methods
- Product Name:METHYL 2-AMINO-5-(4-FLUOROPHENYL)-1,3-THIAZOLE-4-CARBOXYLATE
- CAS Number:886361-30-4
- Molecular formula:C11H9FN2O2S
- Molecular Weight:252.26
Yield:-
Reaction Conditions:
in acetone at 57; for 24 h;
Steps:
A.1.5.2
A solution of the respective α-oxo-ester (22.1 mmol, 1.0 eq) in acetone (25 mL) is added to a suspension of thiourea (22.1 mmol, 1.0 eq) in acetone (45 mL). The mixture is heated to 57° C. (bath temperature), stirred for 24 h and concentrated to half of the volume. The obtained suspension is filtered and the residue is washed with acetone. After drying the desired amino-thiazole derivative is obtained as a solid.
References:
US2010/222328,2010,A1 Location in patent:Page/Page column 23