1-[2-[(tert-Butyldiphenylsilyl)oxy]ethyl]piperazine synthesis

Yield:887583-71-3 96%

Reaction Conditions:

with pyridine;N,N-dimethyl-4-aminopyridine in dichloromethane at 18 - 25;

Steps:

20 1-(2-(tert-Butyldiphenylsilyloxy)ethyl)piperazine

2-(piperazin-1-yl)ethanol (1.000 g, 7.68 mmol) was dissolved in DCM (35.1 ml) and pyridine (0.932 ml, 11.52 mmol) followed by DMAP (0.094 g, 0.77 mmol) were added. tert-butylchlorodiphenylsilane (2.368 ml, 9.22 mmol) was added to the solution and the reaction mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure and the concentrate was purified by column chromatography (ISCO, eluting with 10% MeOH/DCM) to give the title product (2.73 g, yield: 96%). LCMS: (ESI) m/z 369 [M+H]⁺.

References:

US2012/35134,2012,A1 Location in patent:Page/Page column 38