3-AMINOMETHYL-THIOPHENE-2-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium azide / N,N-dimethyl-formamide / 2 h / 110 °C
2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 20 °C

References:

Venskutonytè, Raminta;Butini, Stefania;Sanna Coccone, Salvatore;Gemma, Sandra;Brindisi, Margherita;Kumar, Vinod;Guarino, Egeria;Maramai, Samuele;Valenti, Salvatore;Amir, Ahmad;Valadés, Elena Antón;Frydenvang, Karla;Kastrup, Jette S.;Novellino, Ettore;Campiani, Giuseppe;Pickering, Darryl S. [Journal of Medicinal Chemistry,2011,vol. 54,# 13,p. 4793 - 4805]