![](/CAS/GIF/889948-55-4.gif)
4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER synthesis
- Product Name:4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS Number:889948-55-4
- Molecular formula:C16H25N3O2
- Molecular Weight:291.39
![TERT-BUTYL 4-(3-CYANOPHENYL)PIPERAZINE-1-CARBOXYLATE](/CAS/GIF/807624-20-0.gif)
807624-20-0
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![4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/889948-55-4.gif)
889948-55-4
33 suppliers
$110.00/50mg
Yield:889948-55-4 100%
Reaction Conditions:
with ammonia;hydrogen;nickel in tetrahydrofuran;methanol;water monomer at 20; under 760.051 Torr; for 4 h;
Steps:
1,1-Dimethylethyl 4-[3-(aminomethyl)phenyl]piperazine-1-carboxylate (41)
A mixture of compound 40 (2.00 g, 6.96 mmol), Raney Ni (2.0 g), 28% aqueous NH3 solution (20 mL), THF (20 mL) and methanol (20 mL) was stirred at room temperature for 4 h under hydrogen atmosphere (1 atm). The catalyst was removed by vacuum filtration through a PTFE membrane and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate, dried over Na2SO4, and concentrated under reduced pressure to give the title compound as a pale blue oil (2.03 g, 6.97 mmol, quant.). 1H NMR (300 MHz, DMSO-d6) d 1.42 (9H, s), 3.04-3.13 (4H, m), 3.17-3.51 (6H, m), 3.50-3.82 (2H, m), 6.71-6.80 (2H, m), 6.92 (1H, br s), 7.16 (1H, t, J = 7.2 Hz).
References:
Nara, Hiroshi;Sato, Kenjiro;Kaieda, Akira;Oki, Hideyuki;Kuno, Haruhiko;Santou, Takashi;Kanzaki, Naoyuki;Terauchi, Jun;Uchikawa, Osamu;Kori, Masakuni [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 23,p. 6149 - 6165]
![1-(3-Bromophenyl)piperazine](/CAS/GIF/31197-30-5.gif)
31197-30-5
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$20.00/250mg
![4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/889948-55-4.gif)
889948-55-4
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$110.00/50mg
![4-(3-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/327030-39-7.gif)
327030-39-7
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$30.00/250mg
![4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/889948-55-4.gif)
889948-55-4
33 suppliers
$110.00/50mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
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$13.50/25G
![4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/889948-55-4.gif)
889948-55-4
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$110.00/50mg
![tert-Butyl 1-piperazinecarboxylate](/CAS/GIF/57260-71-6.gif)
57260-71-6
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$5.00/5g
![4-(3-AMINOMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER](/CAS/GIF/889948-55-4.gif)
889948-55-4
33 suppliers
$110.00/50mg