1-(4'-Chlorobiphenyl-3-yl)ethan-1-one, 3-(4-Chlorophenyl)acetophenone synthesis
- Product Name:1-(4'-Chlorobiphenyl-3-yl)ethan-1-one, 3-(4-Chlorophenyl)acetophenone
- CAS Number:893734-59-3
- Molecular formula:C14H11ClO
- Molecular Weight:230.69
637-87-6
288 suppliers
$38.00/10g
2142-63-4
390 suppliers
$5.00/10g
893734-59-3
11 suppliers
$170.00/250MG
Yield:893734-59-3 85%
Reaction Conditions:
Stage #1: 1-Chloro-4-iodobenzenewith TurboGrignard in tetrahydrofuran at -20; for 1 h;Inert atmosphere;
Stage #2: with lithium chlorozincate in tetrahydrofuran;Inert atmosphere;
Stage #3: 1-(3-Bromophenyl)ethanonewith bis(dibenzylideneacetone)-palladium(0);ruphos in tetrahydrofuran at 25; for 0.0833333 h;Inert atmosphere;Negishi cross-coupling reaction;
References:
Kienle, Marcel;Knochel, Paul [Organic Letters,2010,vol. 12,# 12,p. 2702 - 2705] Location in patent:supporting information; experimental part