4'-(1,3-DIOXOLAN-2-YL)[1,1'-BIPHENYL]-4-CARBALDEHYDE synthesis
- Product Name:4'-(1,3-DIOXOLAN-2-YL)[1,1'-BIPHENYL]-4-CARBALDEHYDE
- CAS Number:893737-04-7
- Molecular formula:C16H14O3
- Molecular Weight:254.28
10602-01-4
105 suppliers
$22.00/1g
87199-17-5
431 suppliers
$8.00/5g
893737-04-7
14 suppliers
$362.00/500mg
Yield:893737-04-7 73.9%
Reaction Conditions:
with tetrabutylammomium bromide;potassium carbonate in water at 90 - 100; for 3 h;
Steps:
1.2
A 500 ml flask was charged with compound (261-b) (27.2 g, 0.119 mol), 4-formylphenylboronic acid (27.2 g, 0.136 mol), potassium carbonate (32 . 8 g, 0.237 mol), tetrabutylammonium bromide (11.5 g, 0.0 36 mol), Pd-132 (84 mg, 0.119 mmol), and water (272 ml ), And the mixture was stirred at 90 ° C. to 100 ° C. for 3 hours. The reaction mixture was warmed to room temperature and then toluene (100 ml × 3). The extract was washed with saturated brine, dried over anhydrous magnesium sulfate Dried and concentrated under reduced pressure. The residue was purified by silica gel chromatography (Kieselgel 60; Toluene) to obtain aldehyde (261-c) (22.3 g, 0.0879 mol; yield Rate of 73.9%)
References:
JP2017/39710,2017,A Location in patent:Paragraph 0153
10602-01-4
105 suppliers
$22.00/1g
893737-04-7
14 suppliers
$362.00/500mg
1122-91-4
689 suppliers
$9.00/10g
893737-04-7
14 suppliers
$362.00/500mg