ChemicalBook CAS DataBase List N-Methyl-1-(phenylmethyl)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole-5-ethanesulfonamide

N-Methyl-1-(phenylmethyl)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole-5-ethanesulfonamide synthesis

8synthesis methods

Product Name:N-Methyl-1-(phenylmethyl)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole-5-ethanesulfonamide
CAS Number:894351-86-1
Molecular formula:C24H29N3O2S
Molecular Weight:423.57

N-Methyl-1-(phenylMethyl)-1H-indole-5-ethanesulfonaMide

894351-85-0
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1445-73-4 Synthesis

1445-73-4
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N-Methyl-1-(phenylmethyl)-3-(1,2,3,6-tetrahydro-1-methyl-4-pyridinyl)-1H-indole-5-ethanesulfonamide

894351-86-1
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Yield:-

Reaction Conditions:

with potassium hydroxide in methanol at 60 - 65; for 8 h;Aldol Condensation;

Steps:

14

2-(1-benzyl-1 H-indol-5-yl)-ethanesulfonic acid methylamide (100 g) was dissolved in methanol (1000 ml) and N-methyl-4-piperidone (100 ml) was added thereto at 25⁰C. The reaction mass was stirred for 15 minutes and potassium hydroxide (200 g) was added at 25⁰C. The reaction mass was heated to 60-65⁰C for 8 hours and cooled gradually to 25⁰C. Water (2500 ml) was added slowly and stirred the mixture till solid is obtained. The solid was filtered and dried at 50-55⁰C under vacuum to obtain the title compound (Yield: 98 g, HPLC purity : 99%).

References:

WO2011/21000,2011,A2 Location in patent:Page/Page column 39

894351-84-9 Synthesis