Benzenesulfonic acid, 4-(5-methyl-3-phenyl-4-isoxazolyl)-, sodium salt (1:1) synthesis

Yield:-

Reaction Conditions:

with sodium chloride in water at 0 - 30; for 2 h;

Steps:

2

EXAMPLE 2: 4- [ (5-methyl-3-phenyl)-4-isoxazolyl] benzenesulfonate sodium salt. (step lb) The sulphonic acid obtained in example 1 is dissolved in 185 ml water and sodium chloride (37 g, 0.6324 mol) is added portion wise at a temperature of 25-30 °C. The turbid reaction mass is then cooled to 0-5 °C, stirred for 2 h and filtered. The wet material is then washed with chilled water (74 ml) and dried at 70-75 °C under vacuum for 8-10 h to yield white solid. (38 g, HPLC purity =99.5%, Moisture content = 4.6%)

References:

WO2005/85218,2005,A1 Location in patent:Page/Page column 8