1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID synthesis

5synthesis methods

Product Name:1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID
CAS Number:89960-36-1
Molecular formula:C13H11NO3
Molecular Weight:229.23

3-Pyridinecarboxylic acid, 1,2-dihydro-2-oxo-1-(phenylmethyl)-, methyl ester

400082-66-8
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1-BENZYL-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBOXYLIC ACID

89960-36-1
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$79.75/1g

Yield:89960-36-1 97.6%

Reaction Conditions:

with lithium hydroxide monohydrate;water in methanol at 20; for 4 h;

Steps:

14 1-Benzyl-2-oxo-l,2-dihydropyridine-3-carboxylic acid (lnt-12)

To a mixture of compound lnt-11 (500 mg, 2.05mmol) in MeOH (1 mL) and H2O (1 mL) was added Li0H-H20(l72 mg, 4.10 mmol, 2.0eq) and the mixture was stirred at room temperature for 4 h. The mixture was concentrated in vacuo and the pH was adjusted to 3~4 with aqueous HC1 (1 M). The resulting suspension was filtered and the isolated solid was dried to afford compound lnt-12 (460 mg, 97.6%) as a white solid. ESI-MS (EI⁺, m/z): 230.1.

References:

WO2020/6233,2020,A1 Location in patent:Paragraph 0190; 0193-0195

609-71-2 Synthesis