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9-Fluorenone-1-carboxaMide, 97% synthesis

2synthesis methods
-

Yield:42135-37-5 26 %

Reaction Conditions:

Stage #1: 9-oxo-9H-fluorene-1-carboxylic acidwith thionyl chloride;N,N-dimethyl-formamide in dichloromethane;Reflux;
Stage #2: with ammonium hydroxide in dichloromethane at 0 - 20;

References:

Narayanan, Dilip;Tran, Kim T.;Pallesen, Jakob S.;Solbak, Sara M.;Qin, Yuting;Mukminova, Elina;Luchini, Martina;Vasilyeva, Kristina O.;González Chichón, Dorleta;Goutsiou, Georgia;Poulsen, Cecilie;Haapanen, Nanna;Popowicz, Grzegorz M.;Sattler, Michael;Olagnier, David;Gajhede, Michael;Bach, Anders [Journal of Medicinal Chemistry,2022,vol. 65,# 21,p. 14481 - 14526]