6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester synthesis
- Product Name:6-Bromo-8-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester
- CAS Number:907945-82-8
- Molecular formula:C11H11BrN2O2
- Molecular Weight:283.12
Yield:907945-82-8 73.5%
Reaction Conditions:
in ethanol at 90; for 16 h;
Steps:
262 Intermediate 262A: Ethyl 6-bromo-8-methylimidazo[1,2-a]pyridine-2-carboxylate
To a solution of 5-bromo-3-methylpyridin-2-amine (1.1 g, 5.88 mmol) in ethanol (10 mL) was added ethyl 3-bromo-2-oxopropanoate (1.37 g, 7.06 mmol). The reaction mixture was stirred at 90 °C for 16 h. The reaction mixture was concentrated, then triturated with ethyl acetate (2 mL) to get ethyl 6-bromo-8-methylimidazo[1,2-a]pyridine- 2-carboxylate (1.42 g, 4.32 mmol, 73.5% yield) as pale yellow solid. MS (M+1) m/z: 285 (MH+). LC retention time 1.08 min [L].
References:
WO2019/99336,2019,A1 Location in patent:Page/Page column 196