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ChemicalBook CAS DataBase List 3-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL)BENZOIC ACID
908334-19-0

3-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL)BENZOIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,2-dimethoxyethane / 12 h / 80 °C
2: acetic acid; hydrogen; palladium 10% on activated carbon / 100 °C / 7757.43 Torr
3: sodium hydrogencarbonate / tetrahydrofuran; water / 12 h / 20 °C
4: water; lithium hydroxide / tetrahydrofuran / 6 h / 0 - 20 °C

References:

Hopkins, Brian T.;Bame, Eris;Bell, Noah;Bohnert, Tonika;Bowden-Verhoek, Jon K.;Bui, Minna;Cancilla, Mark T.;Conlon, Patrick;Cullen, Patrick;Erlanson, Daniel A.;Fan, Junfa;Fuchs-Knotts, Tarra;Hansen, Stig;Heumann, Stacey;Jenkins, Tracy J.;Marcotte, Douglas;McDowell, Bob;Mertsching, Elisabeth;Negrou, Ella;Otipoby, Kevin L.;Poreci, Urjana;Romanowski, Michael J.;Scott, Daniel;Silvian, Laura;Yang, Wenjin;Zhong, Min [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 13,p. 2905 - 2913]