4-Amino-6-methoxyquinoline-3-carboxylic acid ethyl ester synthesis
- Product Name:4-Amino-6-methoxyquinoline-3-carboxylic acid ethyl ester
- CAS Number:908350-29-8
- Molecular formula:C13H14N2O3
- Molecular Weight:246.26
22931-71-1
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908350-29-8
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$308.00/1g
Yield:908350-29-8 92%
Reaction Conditions:
with ammonia in isopropyl alcohol;
Steps:
1.a ethyl-4-amino-6-methoxyquinoline-3-carboxylate
Example 1a ethyl-4-amino-6-methoxyquinoline-3-carboxylate A mixture of ethyl 4-chloro-6-methoxyquinoline-3-carboxylate (Example 1b, 796 mg, 3.0 mmol) and ammonia (25% aqueous solution, 10 mL) in isopropanol (40 mL) was stirred at 110° C. in a pressure reactor overnight. Most of the solvent was then removed under reduced pressure, and the reaction mixture was diluted with water. The precipitate was collected by filtration, washed with cold water, and dried under vacuum to give the title compound as an off-white solid (680 mg, 92%). 1H NMR (400 MHz, DMSO-d6) δ 1.33 (t, J=7.0 Hz, 3H), 3.88 (s, 3H), 4.32 (q, J=7.0 Hz, 2H), 7.36 (dd, J=2.8, 8.8 Hz, 1H), 7.72 (d, J=8.8 Hz, 1H), 7.74 (d, J=2.8 Hz, 1H), 8.23 (bs, 2H), 8.77 (s, 1H). MS 247 (MH+).
References:
US2011/245353,2011,A1
77156-78-6
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908350-29-8
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104-94-9
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908350-29-8
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87-13-8
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908350-29-8
13 suppliers
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