2-Chloro-3-iodo-5-[(2S)-1-Methyl-2-pyrrolidinyl]-pyridine synthesis
- Product Name:2-Chloro-3-iodo-5-[(2S)-1-Methyl-2-pyrrolidinyl]-pyridine
- CAS Number:909193-59-5
- Molecular formula:C10H12ClIN2
- Molecular Weight:322.57
112091-17-5
18 suppliers
$215.00/100mg
909193-59-5
6 suppliers
$1230.00/250mg
Yield:909193-59-5 74%
Reaction Conditions:
Stage #1: (S)-6-chloronicotinewith 2,2,6,6-tetramethylpiperidinyl-lithium in tetrahydrofuran at -78; for 1 h;
Stage #2: with iodine in tetrahydrofuran at -78;
References:
Wagner, Florence F.;Comins, Daniel L. [Organic Letters,2006,vol. 8,# 16,p. 3549 - 3552]