2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE synthesis

1synthesis methods

Product Name:2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
CAS Number:91225-69-3
Molecular formula:C13H8Cl2N2OS
Molecular Weight:311.19

2-AMINO-4-(4-CHLORO-PHENYL)-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

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107-14-2 Synthesis

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2-(CHLOROMETHYL)-5-(4-CHLOROPHENYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE

91225-69-3
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Yield:91225-69-3 78%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane; for 6 h;Cooling;

References:

Kathiravan, Matthu K.;Shishoo, Chamanlal J.;Kumar, Krishnan Girish;Roy, Saroj Kumar;Mahadik, Kakasheb R.;Kadam, Shivajirao S.;Jain, Kishor S. [Arzneimittel-Forschung/Drug Research,2007,vol. 57,# 9,p. 599 - 606]