tert-butyl 7-formyl-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate synthesis

3synthesis methods

Product Name:tert-butyl 7-formyl-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate
CAS Number:912270-39-4
Molecular formula:C14H18N2O3
Molecular Weight:262.3

445490-78-8 Synthesis

1-BOC-7-(2-HYDROXYETHYL)-3,4-DIHYDRO-1,8-NAPHTHYRIDINE

445490-78-8
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tert-butyl 7-formyl-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxylate

912270-39-4
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: 89 percent / I₂; imidazole; triethylamine / triphenylphosphine / CH₂Cl₂ / 0 - 25 °C
2: 53 percent / potassium tert-butoxide / tetrahydrofuran / -78 - 20 °C
3: 57 percent / sodium periodate; 4-methylmorpholine-N-oxide; OsO₄ / acetonitrile; H₂O / 20 °C

References:

Raboisson, Pierre;DesJarlais, Renee L.;Reed, Rolanda;Lattanze, Jennifer;Chaikin, Margery;Manthey, Carl L.;Tomczuk, Bruce E.;Marugan, Juan Jose [European Journal of Medicinal Chemistry,2007,vol. 42,# 3,p. 334 - 343]

1,8-Naphthyridine-1(2H)-carboxylic acid, 7-ethenyl-3,4-dihydro-, 1,1-dimethylethyl ester

912270-30-5
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912270-39-4
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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912270-39-4
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References