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91362-43-5

1,2,4-Oxadiazol-3-amine,5-(1,1-dimethylethyl)-(9CI) synthesis

1synthesis methods
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Yield:91362-43-5 50%

Reaction Conditions:

Stage #1: 5-methyl-[1,2,4]oxadiazol-3-ylamine;pivaloyl chloridewith pyridine in benzene; for 8 h;Heating;
Stage #2: in ethanol; for 12 h;Heating;
Stage #3: with hydrogenchloride for 4 h;Heating;

References:

Buscemi, Silvestre;Pace, Andrea;Frenna, Vincenzo;Vivona, Nicolo? [Heterocycles,2002,vol. 57,# 5,p. 811 - 823]