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914348-88-2

4-(4-Acetyl-piperazin-1-yl)-2-trifluoromethylaniline synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium carbonate / dimethyl sulfoxide / 4 h / 90 °C
2: nickel(II) chloride hexahydrate; sodium tetrahydroborate / methanol; dichloromethane / 1 h / 0 °C

References:

Chen, Wenteng;Liu, Shuangrong;Liu, Xingyu;Pan, Youlu;Shao, Jiaan [Bioorganic and Medicinal Chemistry,2020,vol. 28,# 19,art. no. 115680]

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