2-[4-[(6-Bromo-3-nitroquinolin-4-yl)amino]phenyl]-2-methylpropionitrile synthesis

11synthesis methods

Product Name:2-[4-[(6-Bromo-3-nitroquinolin-4-yl)amino]phenyl]-2-methylpropionitrile
CAS Number:915019-51-1
Molecular formula:C19H15BrN4O2
Molecular Weight:411.26

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2-(4-AMINOPHENYL)-2-METHYLPROPANENITRILE

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2-[4-[(6-Bromo-3-nitroquinolin-4-yl)amino]phenyl]-2-methylpropionitrile

915019-51-1
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Yield:915019-51-1 90%

Reaction Conditions:

with acetic acid at 20; for 2 h;

Steps:

6 ynthesis of intermediate 6:

12 g (75 mmol) of intermediate 5 were dissolved in 300 ml of glacial acetic acid,13 g (45.2 mmol) of intermediate 3 was slowly added,Room temperature reaction 2h,Add a lot of water,A yellow solid precipitation, filtration, washed with yellow solid intermediate 6 16.81 g, yield 90%

References:

CN104411706,2016,B Location in patent:Paragraph 0203-0204

71825-51-9 Synthesis