3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one synthesis

7synthesis methods

Product Name:3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one
CAS Number:915307-81-2
Molecular formula:C12H13Cl2N3O2
Molecular Weight:302.16

Pyrido[3,4-b]pyrazine-2,3-dione, 7-chloro-1,4-dihydro-1-(2-propoxyethyl)-

1186508-07-5
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3,7-Dichloro-1-(2-propoxyethyl)-1H,2H-pyrido-[3,4-b]pyrazin-2-one

915307-81-2
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Yield:915307-81-2 80%

Reaction Conditions:

with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 0.5 h;

References:

Hughes, Robert O.;Walker, John K.;Cubbage, Jerry W.;Fobian, Yvette M.;Rogier, D. Joseph;Heasley, Steve E.;Blevis-Bal, Rhadika M.;Benson, Alan G.;Owen, Dafydd R.;Jacobsen, E. Jon;Freskos, John N.;Molyneaux, John M.;Brown, David L.;Stallings, William C.;Acker, Brad A.;Maddux, Todd M.;Tollefson, Mike B.;Williams, Jennifer M.;Moon, Joseph B.;Mischke, Brent V.;Rumsey, Jeanne M.;Zheng, Yi;MacInnes, Alan;Bond, Brian R.;Yu, Ying [Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,# 15,p. 4092 - 4096] Location in patent:scheme or table

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