ChemicalBook CAS DataBase List 5-broMo-1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

5-broMo-1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid synthesis

3synthesis methods

Product Name:5-broMo-1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid
CAS Number:916326-81-3
Molecular formula:C8H6BrN3O2
Molecular Weight:256.06

916326-80-2 Synthesis

Methyl 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylate

916326-80-2
25 suppliers
$297.00/100mg

5-broMo-1-Methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid

916326-81-3
21 suppliers
$391.00/100mg

Yield:916326-81-3 90%

Reaction Conditions:

Stage #1: 5-bromo-1methyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid methyl esterwith sodium hydroxide;water in methanol at 80; for 2 h;
Stage #2: with hydrogenchloride in methanol;water at 20; pH=3 - 4;

Steps:

11

Compound 11a (0.31 g) was dissolved in MeOH (5 mL) and 10% aqueous sodium hydroxide solution (5 mL) and heated at 80 ⁰C for two hours. The solution was cooled to room temperature before it was acidified by hydrochloric acid (IM solution) EPO to pH 3 to 4. Precipitate was collected and washed with additional water and dried to afford 5-bromo-l-methyl-lH-pyrazolo[3,4-b]pyridine-3-carboxylic acid Compound lib (0.26 g, 90%) as a white solid. MS (ESI) m/z: 257 (M+H⁺).

References:

WO2006/130673,2006,A1 Location in patent:Page/Page column 102-103

Methyl 1H-pyrazolo[3,4-b]pyridine-3-carboxylate

916325-83-2
64 suppliers
$63.00/100mg

916326-81-3
21 suppliers
$391.00/100mg

References

ethyl 5-chloro-[1,2,4]triazolo[4,3-a]pyrimidine-7-carboxylat

916325-84-3
62 suppliers
$100.00/100mg

916326-81-3
21 suppliers
$391.00/100mg

References