3-Aminotetrahydrofuran-3-carboxylic acid hydrochloride synthesis

Yield:919098-94-5 100%

Reaction Conditions:

with hydrogenchloride;water at 20; for 1 h;

Steps:

1.d

(d) S-amino-tetrahydro-furan-S-carboxylic acid-hydrochloride3.5 g (15.1 mmol) S-terf.-butoxycarbonylamino-tetrahydro-furan-S-carboxylic acid are dissolved in 150 ml of 1 -molar hydrochloric acid and stirred for 1 h at room temperature. Then the reaction mixture is lyophilised. Yield: 2.5 g (100 %) C₅H₉NO₃^*HCI (167.59)Mass spectrum: (M+H)⁺ = 132

References:

WO2008/80891,2008,A2 Location in patent:Page/Page column 108-109