(2E)-3-(3-bromophenyl)-1-(4-bromophenyl)prop-2-en-1-one synthesis
- Product Name:(2E)-3-(3-bromophenyl)-1-(4-bromophenyl)prop-2-en-1-one
- CAS Number:919121-16-7
- Molecular formula:C15H10Br2O
- Molecular Weight:366.05
Yield:919121-16-7 97%
Reaction Conditions:
Stage #1: 1-(3-Bromophenyl)ethanonewith sodium hydroxide in ethanol;water at 0; for 1.5 h;
Stage #2: 4-bromo-benzaldehyde in ethanol;water at 20;
Steps:
3.S1 S1: Synthesis of ((E)-3-(3-bromophenyl)-1-(4-bromophenyl)prop-2-en-1-one):
7 g of NaOH was dissolved in 15 ml of water, 25 ml of ethanol was added, the temperature was lowered to 0 ° C, m-bromoacetophenone (19.9 g, 100 mmol, 1 eq) was added, and vigorously stirred for 1.5 h.Then, p-bromobenzaldehyde (18.5 g, 100 mmol, 1 eq) was added dropwise. After the dropwise addition was completed, the reaction system was stirred to room temperature and stirred until it was stirred, and placed in a refrigerator overnight.Filter, wash with water, wash with ethanol, spin dry ethanol to give 35.3 g (97%)
References:
CN108285452,2018,A Location in patent:Paragraph 0095; 0097; 0099; 0100
