2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride synthesis
- Product Name:2-(Chloromethyl)-5-methyl-1,3-thiazole hydrochloride
- CAS Number:921145-23-5
- Molecular formula:C5H6ClNS
- Molecular Weight:147.63
202932-04-5
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Yield:921145-23-5 570 mg
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 2 h;
Steps:
4.2 Step 2 2-(chloromethyl)-5-methylthiazole
Step 2 2-(chloromethyl)-5-methylthiazole To a solution of (5-methylthiazol-2-yl)methanol (0.5 g, 3.87 mmol) in DCM (5 mL) was added thionyl chloride (0.19 ml, 2.6 mmol) at 0 °C, then the mixture was stirred at room temperature for 2 h. The solvent was concentrated to give 2-(chloromethyl)-5-methylthiazole (570 mg) as a yellow oil which was used without purification. LCMS retention time 0.912 min; LCMS MH+ 148.
References:
WO2014/143799,2014,A2 Location in patent:Page/Page column 368; 369
13838-78-3
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