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2-HYDROXY-5-(4-METHOXY-PHENYLSULFAMOYL)-BENZOIC ACID synthesis
- Product Name:2-HYDROXY-5-(4-METHOXY-PHENYLSULFAMOYL)-BENZOIC ACID
- CAS Number:92200-76-5
- Molecular formula:C14H13NO6S
- Molecular Weight:0
Yield:-
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 16 h;
Steps:
543
A solution of 5-chlrosulfonylsalicylic acid (0.96 g, 4.1 mmol) in dichloromethane (20 ml_) and triethylamine (1 .69 ml_, 12.2 mmol) was added p-anisidine (0.49 g, 4.1 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The mixture was added dichloromethane (50 ml_) and was washed with water (2 x 100 ml_). Drying (MgSO4) of the organic phase and concentration in vacuo afforded 0.57 g crude product. Purification by column chromatography on silica gel eluting first with ethyl acetate: heptane (1 :1 ) then with methanol afforded 0.1 g of the title compound.HPLC-MS (Method A): m/z: 346 (M+23); Rt = 2.89 min. EPO
References:
WO2006/82245,2006,A1 Location in patent:Page/Page column 248-249